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Humulin R U-100 is indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus. Humulin R U-100 may be administered intravenously under proper medical supervision in a clinical setting for glycemic control.It takes effect rapidly and has a relatively short duration of activity (4 to 12 hours) as compared with other insulins.